A 21-year-old female Medical Student was brought to the emergency department with nausea, vomitting & complaint of abdominal pain. She had been under a lot of stress preparing for her final examinations. In her hostel, her friends noticed an empty bottle of paracetamol near the bed with numerous pills lying on the ground. On arrival to the emergency department, the patient was found distressed with vomiting. Laboratory tests revealed normal white blood cell count; hypokalemia; elevated liver enzymes; paracetamol level was above 200femtogram/ML.
The emergency Dept physician gave a gastric lavage and then prescribed oral N-acetylcysteine. What is the pathophysiology of the liver toxicity? How does N-acetylcysteine helps in this condition?